Small Molecule Chemical Probes

 The Koehler Lab has developed small molecule probes of proteins involved in various cellular pathways
to elucidate their functions and rigorously validate therapeutic opportunities.

For each probe listed below, 'target' links provide information about the motivation for developing the probe against the target
and 'probe' links provide descriptive information about the small molecule probe, 
including commercial sources for the probe if available.

To learn more about chemical probes within the wider research community, please visit chemicalprobes.org
To connect with the wider research ecosystem prioritizing chemical probe development, please connect with the Target 2035 federation.

 
 
chemical structure for KI-ARv-03
 

Target: CDK9

Probe: KI-ARv-03

 
compound52-01.png
 

Target: IL-4

Probe: Nico-052 (e.g. compound 52 from manuscript)

 
KI-MS2-008.jpeg
 

Target:  Max

Probe:  KI-MS2-008

 
 
ETV1-BRD32048.png
 
 
 
Orai1_AnCoA4.png
 

Target:  Orai1

Probe:  AnCoA4

 
 
HDAC_BRD2577.png
 
 
 
 

Target:  Amyloid-β

Probe:  2002-H20

 
 
hedgehog_Robotnikinin.png
 

Target:  Sonic Hedgehog (Shh)

Probe:  Robotnikinin

 
 
 

Target:  SR-BI

Probe:  BLT-1

 
 
calmodulin_Calmoduphilin.png
 

Target:  Calmodulin

Probe:  Calmoduphilin

 
 
 

Target:  Hap3p

Probe:  Haptamide B

 
 
 
 
 
 
 
 
pde3a_DNMDP.png