Probes

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 The Koehler lab has developed small-molecule probes of proteins involved in various cellular pathways.  Each target link provides information about the probe, including commercial sources.

 

 

Target:  ETS Translocation Variant 1 (ETV1)

ProbeBRD32048

 

 

Target:  Orai1

ProbeAnCoA4

 

 

Target:  Histone Deacetylase (HDAC) Enzyme Family

ProbeBRD2577

 

 

Target:  Amyloid-β

Probe2002-H20

 

 

Target:  Sonic Hedgehog (Shh)

ProbeRobotnikinin

 

 

Target:  SR-BI

ProbeBLT-1

 

 

Target:  Calmodulin

Probe:  Calmoduphilin

 

 

Target:  Hap3p

Probe:  Haptamide B

 

 

Target:  Histone Deacetylase 5/9 (HDAC5/9)

Probe:  BRD4354

 

 

Target:  Glycogen Synthase Kinase 3 beta (GSK3β)

ProbeFragment 15R

 

 

Target:  Phosphodiesterase 3 alpha (PDE3α)

ProbeDNMDP

 

 

Target:  Small Heterodimer Partner (SHP)

ProbeDSHN