Koehler Headshot Serious Mark Ostow.jpg

Angela N. Koehler, PhD

Assistant Professor, Department of Biological Engineering, MIT
Intramural Faculty, David H. Koch Institute for Integrative Cancer Research at MIT
Associate Member, Broad Institute of Harvard and MIT

koehler@mit.edu
curriculum vitae

Angela Koehler is the Goldblith Career Development Professor in Applied Biology in the Department of Biological Engineering at MIT and an intramural member of the David H. Koch Institute for Integrative Cancer Research at MIT. She is also an Associate Member of the Broad Institute. Her research group aims to discover and develop functional small-molecule probes of transcriptional regulators, including chromatin modifying enzymes and oncogenic transcription factors. Validated probes may be used to advance the understanding of transcription in development and disease. Selected probes may be developed into imaging agents, diagnostic tools, or therapeutic leads.

Angela received her B.A. in Biochemistry and Molecular Biology from Reed College in 1997. There she worked under the guidance of Professor Arthur Glasfeld on structural and biochemical studies of proteins that recognize tRNA or DNA. In 2003, she received her Ph.D. in Chemistry from Harvard University where she worked with Professor Stuart Schreiber to develop novel technologies for identifying and characterizing interactions between proteins and small molecules. Upon graduation, she became an Institute Fellow in the Chemical Biology Program at the Broad Institute and a Group Leader for the NCI Initiative for Chemical Genetics.

 

 André Richters, PhD   Postdoctoral Associate  PhD, Chemical Biology, Technische Universität Dortmund, Germany, 2013 MS, Chemical Biology, Technische Universität Dortmund, Germany, 2009 BS, Chemical Biology, Technische Universität Dortmund, Germany, 2007  Research Interests :  I am interested in developing new screening assays to identify small molecule p300 modulators of oncogenic p300/CBP signaling. This includes follow up hit optimization using synthetic chemistry and SAR studies aiming for the development of potent p300 inhibitors or activators.    richters at mit.edu

André Richters, PhD

Postdoctoral Associate
PhD, Chemical Biology, Technische Universität Dortmund, Germany, 2013
MS, Chemical Biology, Technische Universität Dortmund, Germany, 2009
BS, Chemical Biology, Technische Universität Dortmund, Germany, 2007
Research Interests: I am interested in developing new screening assays to identify small molecule p300 modulators of oncogenic p300/CBP signaling. This includes follow up hit optimization using synthetic chemistry and SAR studies aiming for the development of potent p300 inhibitors or activators.
richters at mit.edu

 Brice Curtin, PhD   Postdoctoral Associate  PhD, Organic Chemistry, University of California, Los Angeles, 2017 BS, Chemistry, Missouri University of Science and Technology, 2012  Research Interests :  I am interested in using synthetic organic chemistry and NMR to probe biological structure and mechanisms underpinning cancer.    bcurtin at mit.edu

Brice Curtin, PhD

Postdoctoral Associate
PhD, Organic Chemistry, University of California, Los Angeles, 2017
BS, Chemistry, Missouri University of Science and Technology, 2012
Research Interests: I am interested in using synthetic organic chemistry and NMR to probe biological structure and mechanisms underpinning cancer.
bcurtin at mit.edu

 Andrew Chen   PHD Candidate,  Biological Engineering   Koch Institute Fellow, Cancer Research  BS, Biological Engineering, Cornell University, 2011  Research Interests :  The transcription factor c-Myc is a master regulator aberrant in ~70% of human cancers. My focus involves characterization of lead chemical probes for c-Myc or its major protein partner Max, and discovery of new small molecules that modulate c-Myc activity in specific contexts.   achen5 at mit.edu

Andrew Chen

PHD Candidate, Biological Engineering
Koch Institute Fellow, Cancer Research
BS, Biological Engineering, Cornell University, 2011
Research Interests: The transcription factor c-Myc is a master regulator aberrant in ~70% of human cancers. My focus involves characterization of lead chemical probes for c-Myc or its major protein partner Max, and discovery of new small molecules that modulate c-Myc activity in specific contexts.
achen5 at mit.edu

 Becky Leifer, MS   Research Associate  MS, Biotechnology, Northeastern University, 2014 MS, Organic Chemistry, Northeastern University, 2005 BA, Chemistry, Vassar College, NY, 1998  Research Interests :  I am interested in developing small-molecule probes that target deregulated transcription factors in cancer. This protein class has often been classified as "undruggable", however, with the use of unbiased binding assays such as SMM, we hope to find small molecules that modulate aberrant transcriptional activity.   beleifer at mit.edu

Becky Leifer, MS

Research Associate
MS, Biotechnology, Northeastern University, 2014
MS, Organic Chemistry, Northeastern University, 2005
BA, Chemistry, Vassar College, NY, 1998
Research Interests: I am interested in developing small-molecule probes that target deregulated transcription factors in cancer. This protein class has often been classified as "undruggable", however, with the use of unbiased binding assays such as SMM, we hope to find small molecules that modulate aberrant transcriptional activity.
beleifer at mit.edu

 Catherine Henry   Graduate Student,  Biological Engineering BS, Biomedical Engineering, University of Virginia, 2016  Research Interests :  I am interested in engineering high-throughput technologies to improve SMM screening for “undruggable” targets.   cchenry at mit.edu

Catherine Henry

Graduate Student, Biological Engineering
BS, Biomedical Engineering, University of Virginia, 2016
Research Interests: I am interested in engineering high-throughput technologies to improve SMM screening for “undruggable” targets.
cchenry at mit.edu

 Rob Wilson   PHD Candidate,  Biological Engineering BS, Biochemistry, Purdue University, 2015  Research Interests :  I'm working to find small molecules to perturb oncogenic RAS signaling. I'm especially interested in discovering compounds that can act to destabilize target proteins through inducible ubiquitylation.   rwilson at mit.edu

Rob Wilson

PHD Candidate, Biological Engineering
BS, Biochemistry, Purdue University, 2015
Research Interests: I'm working to find small molecules to perturb oncogenic RAS signaling. I'm especially interested in discovering compounds that can act to destabilize target proteins through inducible ubiquitylation.
rwilson at mit.edu

 Shelby (Pursley) Doyle   PhD Candidate,  Biological Engineering     NSF Graduate Research Fellow,  Ludwig Center for Molecular Oncology Graduate Fellow  BS, Biological Engineering, Louisiana State University, 2014  Research Interests :  I am interested in understanding the role of certain transcription factors in both initiating and progressing disease in hormone-dependent prostate and breast cancer. Towards this goal, I am interested in developing small molecules that modulate these transcription factors as tools for Target and Biomarker Validation.   spursley at mit.edu

Shelby (Pursley) Doyle

PhD Candidate, Biological Engineering
NSF Graduate Research Fellow,
Ludwig Center for Molecular Oncology Graduate Fellow

BS, Biological Engineering, Louisiana State University, 2014
Research Interests: I am interested in understanding the role of certain transcription factors in both initiating and progressing disease in hormone-dependent prostate and breast cancer. Towards this goal, I am interested in developing small molecules that modulate these transcription factors as tools for Target and Biomarker Validation.
spursley at mit.edu

  Nicholas Struntz, PhD    Postdoctoral Fellow   MIT-GSK Gertrude B. Elion Research Fellow,   Ludwig Center for Molecular Oncology Post-doctoral Fellow  PhD, Medicinal Chemistry, University Minnesota, 2016 BS, Chemistry/ Biochemistry, University of Minnesota-Duluth, 2009  Research Interests :  I am interested in discovering and characterizing small molecule binders of the Myc transcription factor, which is one of the most common oncogenic events in human cancer. I am also evaluating the mechanism of how these small molecules perturb Myc function.   nstruntz at mit.edu

Nicholas Struntz, PhD

Postdoctoral Fellow
MIT-GSK Gertrude B. Elion Research Fellow,
Ludwig Center for Molecular Oncology Post-doctoral Fellow
PhD, Medicinal Chemistry, University Minnesota, 2016
BS, Chemistry/ Biochemistry, University of Minnesota-Duluth, 2009
Research Interests: I am interested in discovering and characterizing small molecule binders of the Myc transcription factor, which is one of the most common oncogenic events in human cancer. I am also evaluating the mechanism of how these small molecules perturb Myc function.
nstruntz at mit.edu

 

High Throughput Screening Facility

Associates

 Amedeo Vetere, PhD   Research Scientist ,   Wagner Laboratory   , Broad Institute   avetere at broadinstitute.org

Amedeo Vetere, PhD

Research Scientist, Wagner Laboratory, Broad Institute
avetere at broadinstitute.org

 
 Jaime Cheah, PhD   Core Leader ,   HTS Facility    jcheah at mit.edu   Christian Soule   Lead Automation Engineer Specialist ,   HTS Facility    csoule at mit.edu

Jaime Cheah, PhD

Core Leader, HTS Facility
jcheah at mit.edu

Christian Soule

Lead Automation Engineer Specialist, HTS Facility
csoule at mit.edu