Published Protocols for Small-Molecule Microarray Screening

A Method for the Covalent Capture and Screening of Diverse Small Molecules in a Microarray Format
2006 Nature Protocol for manufacturing arrays for isocyanate-mediated capture of small molecule libraries and screening a purified protein of interest

Ligand Discovery Using Small-Molecule Microarrays
2012 Methods in Molecular Biology: Chemical Proteomics protocol with updated information regarding array design and positive control screening with purified FKBP-12

Probing Small-Molecule Microarrays with Tagged Proteins in Cell Lysates
2015 Current Protocol in Chemical Biology protocol with updated information for screening targets from cell lysates

 

Informal "SMM 101" documentation created in the lab for collaborators and undergraduate students.

Click through below or download .pdf here.