Research

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The Koehler lab is focused on building chemical tools and methods for studying temporal aspects of transcriptional regulation in development and disease with a focus on cancer. The lab pursues these goals by discovering and developing direct small-molecule probes of proteins involved in transcriptional regulation such as  transcription factors and chromatin modifying enzymes.

Small-molecule probes of oncogenic transcription factors

Small-molecule probes of oncogenic transcription factors

Our team is developing a general approach to small-molecule probe discovery for transcription factors by coupling a high-throughput binding assay involving small-molecule microarrays (SMMs) with functional assays involving transcriptional and cellular readouts. more >>

Structurally and mechanistically novel probes of deacetylase enzymes

Structurally and mechanistically novel probes of deacetylase enzymes

Histone deacetylases (HDACs) have emerged as valuable targets for small-molecule probes and drugs due to their fundamental role in transcriptional regulation and implication in several diseases. more >>

Small-molecule microarrays

Small-molecule microarrays

Over the last decade, small-molecule microarrays (SMMs) have proven to be a general, robust and scalable screening platform for discovering protein-small molecule interactions that lead to modulators of protein function. more >>